2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W278072R
    Calcium Channel antagonist 1 (Standard) 43067-01-2
    Calcium Channel antagonist 1 (Standard) is the analytical standard of Calcium Channel antagonist 1. This product is intended for research and analytical applications. Calcium Channel antagonist 1 is an antagonist of Calcium Channel Calcium Channel antagonist 1 has the potential for the research of neurology disease.
    Calcium Channel antagonist 1 (Standard)
  • HY-W385577A
    (S)-2-Benzylpyrrolidine hydrochloride 98%
    (S)-2-Benzylpyrrolidine hydrochloride (Compound s1) serves as a METH hapten scaffold. (S)-2-Benzylpyrrolidine hydrochloride attenuates Methamphetamine-induced hyperlocomotion, hyperthermia and respiratory depression. (S)-2-Benzylpyrrolidine hydrochloride alleviates Fentanyl-induced respiratory depression.
    (S)-2-Benzylpyrrolidine hydrochloride
  • HY-W403046A
    D-myo-Inositol-4-phosphate monoammonium
    D-myo-Inositol-4-phosphate monoammonium is a metabolite of D-myo-Inositol 1,4,5-trisphosphate. D-myo-Inositol 1,4,5-trisphosphate, a second messenger, elicits Ca2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2) .
    D-myo-Inositol-4-phosphate monoammonium
  • HY-W415121R
    Bupivacaine hydrochloride monohydrate (Standard) 73360-54-0
    Bupivacaine (hydrochloride monohydrate) (Standard) is the analytical standard of Bupivacaine (hydrochloride monohydrate). This product is intended for research and analytical applications. Bupivacaine hydrochloride monohydrate is a NMDA receptor inhibitor. Bupivacaine hydrochloride monohydrate can block sodium, L-calcium, and potassium channels. Bupivacaine hydrochloride monohydrate potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride monohydrate can be used for the research of chronic pain.
    Bupivacaine hydrochloride monohydrate (Standard)
  • HY-W424792A
    O-Desmethyl Brinzolamide hydrochloride 2967475-56-3 98%
    O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a Kd of 0.136 nM for CA II and an IC50 of 165 nM for CA IV.
    O-Desmethyl Brinzolamide hydrochloride
  • HY-W549985S
    Oleoyl-L-carnitine-d3-1 chloride
    Oleoyl-L-carnitine-d3-1 chloride is the deuterium labeled Oleoyl-L-carnitine chloride (HY-W549985). Oleoyl-L-carnitine (chloride) is an active compound and can be used for the research of analytical study.
    Oleoyl-L-carnitine-d3-1 chloride
  • HY-W653762A
    Cetirizine N-oxide dihydrochloride
    Cetirizine N-oxide dihydrochloride is an oxidative degradation product of the histamine H1 receptor antagonist Cetirizine (HY-17042).
    Cetirizine N-oxide dihydrochloride
  • HY-W670564A
    (4S)-10-Nor-calamenen-10-one 1270089-06-9 98%
    (4S)-10-Nor-calamenen-10-one (Compound 15) enhances LPS-induced NO production by microglia. (4S)-10-Nor-calamenen-10-one is an eudesmane sesquiterpene that can be isolated from Alpinia oxyphylla.
    (4S)-10-Nor-calamenen-10-one
  • HY-W709349S
    Flupirtine-d6 hydrochloride 98%
    Flupirtine-d6 (D 9998-d6) hydrochloride is the deuterium labeled Flupirtine hydrochloride (HY-W709349). Flupirtine hydrochloride is an orally active, blood-brain barrier-crossing non-opioid analgesic and neuroprotective agent. Flupirtine hydrochloride is a neuronal potassium channel opener (Kv7 activator), a NMDA receptor antagonist and a GABA receptor activator. Flupirtine hydrochloride stabilizes blood-brain-barrier integrity, reduces oxidative stress and brain leukocyte infiltration, enhances angioneurogenesis, suppresses calcium influx, stabilizes neuronal resting membrane potential, and counteracts focal cerebral ischemia. Flupirtine hydrochloride exhibits analgesic, muscle relaxant properties, protects neurons from excitotoxic, ischemic, or cytokine-mediated death. Flupirtine hydrochloride functions as a non-opioid analgesic without antipyretic or antiphlogistic properties, shows no relevant affinity to opiate receptor. Flupirtine hydrochloride can be used for the research of focal cerebral ischemia, pain, Alzheimer’s disease, or multiple sclerosis.
    Flupirtine-d6 hydrochloride
  • HY-W709976A
    MTTA 403860-66-2 98%
    MTTA (mephtetramine) is a psychoactive substance. MTTA can be used as stimulant.
    MTTA
  • HY-W719019A
    2-Methylethcathinone hydrochloride 2705355-07-1 98%
    2-Methylethcathinone (2-MEC) is an isomer of a psychoactive substance.
    2-Methylethcathinone hydrochloride
  • HY-W725190A
    Piperidylthiambutene 54160-31-5 98%
    Piperidylthiambutene is a potent µ-opioid receptor (MOR) agonist with a Ki of 2.75 nM. Piperidylthiambutene exhibits analgesic and antitussive properties and can be utilized in relevant research.
    Piperidylthiambutene
  • HY-W726667A
    (R)-(-)-Citramalic acid lithium 2319882-36-3 98%
    (R)-(-)-Citramalic acid ((R)-Citramalate) lithium, a lithium salt of Citramalic acid, is the R enantiomer of Citramalic acid lithium. (R)-(-)-Citramalic acid lithium is involved in the metabolism of glutamate through the methylaspartate pathway. (R)-(-)-Citramalic acid lithium is promising for research of neurological disorders.
    (R)-(-)-Citramalic acid lithium
  • HY-W748591R
    Cannflavin A (Standard) 76735-57-4
    Cannflavin A (Standard) is the analytical standard of Cannflavin A. This product is intended for research and analytical applications. Cannflavin A can be isolated from Cannabis sativa L.. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO) (IC50 = 29.4 μM). Cannflavin A activates apoptosis via caspase-3 cleavage. Cannflavin A exerts anti-inflammatory effects by inhibiting pro-inflammatory enzymes, including prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line.
    Cannflavin A (Standard)
  • HY-W749852A
    Xanthine sodium, for cell culture 1196-43-6 98%
    Xanthine sodium, for cell culture, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine sodium, for cell culture also acts as an intermediate product on the pathway of purine degradation.
    Xanthine sodium, for cell culture
  • HY-W751808S
    2,3-Diphosphoglyceric acid-13C3 2726226-14-6 98%
    2,3-Diphosphoglyceric acid-13C3 is the 13C-labeled 2,3-Diphosphoglyceric acid (HY-113050). 2,3-Diphosphoglyceric acid (2,3-DPG) is an intermediate of the glycolytic pathway. 2,3-Diphosphoglyceric acid stabilizes the deoxygenated form of hemoglobin by allosteric binding and facilitates oxygen release at tissue sites. 2, 3-diphosphoglyceric acid has antiparasitic activity. 2,3-Diphosphoglyceric acid can be used in the study of Alzheimer's disease (AD).
    2,3-Diphosphoglyceric acid-13C3
  • HY-W758677A
    Fosnetupitant-d6 dihydrochloride
    Fosnetupitant-d6 dihydrochloride (Pronetupitant-d6 dihydrochloride) is the deuterium labeled Fosnetupitant dihydrochloride (HY-W758677A). Fosnetupitant (Pronetupitant) a methylene phosphate proagent of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor.
    Fosnetupitant-d6 dihydrochloride
  • HY-W762011R
    BDE 47 (Standard) 5436-43-1
    BDE 47 (Standard) is the analytical standard of BDE 47. This product is intended for research and analytical applications. BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish.
    BDE 47 (Standard)
  • HY-W774927S
    Acepromazine-d6 hydrochloride 1173022-70-2
    Acepromazine-d6 hydrochloride is the deuterium labeled Acepromazine hydrochloride. Acepromazine (Acetopromazine) is a phenothiazine tranquilizeran and alpha-adrenoceptor antagonist.
    Acepromazine-d6 hydrochloride
  • HY-W801479S
    Edaravone sulfate-d5
    Edaravone sulfate-d5 is the deuterium labeled Edaravone sulfate. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
    Edaravone sulfate-d5
Cat. No. Product Name / Synonyms Application Reactivity